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目的:探讨食管鳞癌组织Survivin的表达情况及其与食管鳞癌临床病理因素及预后的关系。方法:收集中山大学附属肿瘤医院2001-01-01-2006-06-30连续收治112例接受同期放化疗的食管鳞癌患者的临床及病理资料,并应用免疫组化法检测其治疗前肿瘤组织中Survivin的表达情况。分析Sur-vivin的表达情况与各临床病理因素之间的相关性,并采用生存分析方法,寻找影响食管鳞癌预后的独立因素。结果:Survivin的表达可见于肿瘤细胞的胞质和(或)胞核内,胞核表达率为67.8%,胞质表达率为65.2%。在不同肿瘤长度、肿瘤部位、分化程度和TNM分期的食管鳞癌患者中,Survivin在核内或胞质内的表达差异均无统计学意义,P均>0.05。生存分析结果显示,核内和胞质内的Survivin表达对预后均无明显影响。结论:Survivin可能不是食管鳞癌的预后因素,应用免疫组化法检测Survivin对评估食管鳞癌放化疗的预后意义不大。
Objective: To investigate the expression of Survivin in esophageal squamous cell carcinoma and its relationship with clinicopathological factors and prognosis of esophageal squamous cell carcinoma. Methods: The clinical and pathological data of 112 patients with esophageal squamous cell carcinoma treated by concurrent chemoradiotherapy were collected from the Affiliated Tumor Hospital of Sun Yat-sen University from January 2001 to June 2006. The tumor tissues Survivin in the expression. The correlation between the expression of Sur-vivin and clinicopathological factors was analyzed. Survival analysis was used to find out the independent factors influencing the prognosis of esophageal squamous cell carcinoma. Results: The expression of Survivin was found in the cytoplasm and / or nucleus of tumor cells. The expression rate of Survivin was 67.8% and the expression rate of cytoplasm was 65.2%. In patients with esophageal squamous cell carcinoma of different tumor length, tumor location, differentiation degree and TNM stage, there was no significant difference in the expression of Survivin in the nucleus or cytoplasm (P> 0.05). The results of survival analysis showed that the expression of Survivin in nucleus and cytoplasm had no significant effect on prognosis. Conclusion: Survivin may not be a prognostic factor for esophageal squamous cell carcinoma. The detection of Survivin by immunohistochemistry is of little significance in evaluating the prognosis of esophageal squamous carcinoma.