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目的 :观察胆囊运动功能及其与糖尿病程之间的关系。方法 :糖尿病患者 36例 ,分为 A组 (病程大于 5年 ) 18例 ,B组 (病程 5年以下 ) 18例 ,及 C组 (对照组 ) 2 0例。 B超测定空腹和脂肪餐后胆囊容量 ,计算胆囊排空指数 ,比较各组间的差异。结果 :空腹和餐后胆囊容量 ,A组 (2 0 .6 7± 5.6 9ml和 11.6 1± 4 .93ml)与对照组 (17.0 3± 3.2 2和 6 .6 1± 2 .15ml)比较 ,P<0 .0 2和 P<0 .0 0 1。B组 (19.96± 4 .96 ml和 8.56± 2 .77ml)与对照组比较 ,P<0 .0 5和 P<0 .0 2。 A,B两组间比较无差异 ,P>0 .0 5。胆囊排空指数 (gallbladder ejection fraction,GBEF) ,A组 (4 5%± 10 .0 8% )与对照组 (6 1.72 %±7.75% )比较 ,P<0 .0 0 1。 B组 (57.37%± 7.15% )与对照组比较无差异。 A,B两组间比较 P<0 .0 0 1)。结论 :糖尿病患者胆囊容量增加 ,GBEF降低 ,尤以病程超过 5年组明显。胆囊运动功能障碍的程度与糖尿病病程呈正相关 ,自主神经病变可能为重要的发病机制之一。
Objective: To observe the relationship between gallbladder motor function and diabetes duration. Methods: Thirty-six patients with diabetes mellitus were divided into group A (18 patients with more than 5 years of disease duration), group B (duration 5 years or less), and group C (control group) 20 patients. B-fasting and fat measured after the gallbladder volume, calculate the gallbladder emptying index, compare the differences between groups. Results: Compared with the control group (17.0 3 ± 3.2 2 and 6.16 ± 2.15ml), the fasting and postprandial Gallbladder volume in Group A (20.767 ± 5.69ml and 11.61 ± 4.93ml) <0 .0 2 and P <0 .0 0 1. Group B (19.96 ± 4.96 ml and 8.56 ± 2 .77 ml) compared with the control group, P <0. 05 and P <0. There was no difference between A and B groups (P> 0.05). Gallbladder ejection fraction (GBEF) in group A (45.5% ± 10.08%) was significantly lower than that in control group (6 1.72% ± 7.75%), P <0.001. B group (57.37% ± 7.15%) compared with the control group no difference. A, B between the two groups P <0. 0 0 1). Conclusion: The gallbladder volume of diabetic patients increases and GBEF decreases, especially in the course of more than 5 years. Gallbladder dysfunction and the degree of diabetes is positively correlated with the course of disease, autonomic neuropathy may be one of the important pathogenesis.