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使用阿片类止痛药的主要问题在于其产生的副作用,尤其对于门诊患者,如恶心、呕吐、眩晕、困倦和对心血管、呼吸系统的抑制,以及药物依赖性。Seymour研究认为其口腔手术后止痛无效,并不比安慰剂强。 曲马多作为一种阿片类促效药,具有与镇痛新相同的止痛效果,却较后者有明显少的副作用,亦无对呼吸及心血管系统的抑制作用,且极少产生机体依赖和耐受,本实验评价曲马多在牙槽骨手术后止痛的效果。 实验对象为452名18岁以上的门诊患者,局麻下做牙槽骨手术:切骨及缝合术,主要是拔除下颌阻生第三磨牙。根据计算机随机程序预备做双盲实验,以安慰
The main problem with opioid analgesics is their side effects, especially for outpatients such as nausea, vomiting, dizziness, sleepiness and cardiovascular, respiratory depression and drug dependence. Seymour's study found no pain after oral surgery and no more than placebo. Tramadol, as an opioid agonist, has the same analgesic effect as analgesics but with significantly less side effects than the latter and no respiratory or cardiovascular inhibitory effects and minimal organ-dependence And tolerance, the experimental evaluation of tramadol analgesia after alveolar bone surgery. The subjects were 452 outpatients over the age of 18 undergoing alveolar bone surgery under local anesthesia: osteotomy and suture, mainly the removal of the third molar impacted mandible. According to randomized computer program to do double-blind experiment to comfort