论文部分内容阅读
本组使用60只家兔,实验观察东莨菪碱对甘油致家兔ARF的防治作用。在实验中做四项检查:(1)肾血流量,(2)血浆A_Ⅱ含量;(3)FE-(Na)、RFI;(4)病理检查。其结果表明,当甘油致家兔ARF在严重缺血时期,东莨菪碱却有解除血管痉挛,改善微循环,增加肾血流量的作用。同时预防组血浆A_Ⅱ含量明显比对照组减少,故认为该药可能抑制A_Ⅱ的产生。通过FE_(Na)、RFI的测定显示该药对肾小管钠重吸收有保护作用。从病理形态上亦可证实用药后肾浊肿明显减轻。
This group of 60 rabbits, experimental observation of scopolamine on rabbit ARF prevention and treatment of glycerol. In the experiment to do four checks: (1) renal blood flow, (2) plasma A_Ⅱ content; (3) FE- (Na), RFI; (4) pathological examination. The results showed that when glycerol-induced rabbit ARF in a period of severe ischemia, scopolamine have to relieve vasospasm, improve microcirculation and increase renal blood flow. In the meantime, the content of A_Ⅱ in the prevention group was significantly lower than that in the control group, so the drug may inhibit A_Ⅱ production. By FE_ (Na), the determination of RFI showed that the drug has a protective effect on tubular sodium reabsorption. From the pathological morphology can also be confirmed after administration of renal turbidity significantly reduced.