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目的开展经腹绒毛取材在早孕期产前诊断中的应用,提前产前诊断的时间窗口。方法早孕期采用经腹绒毛取材125例,其中人工流产组38例,产前诊断87例。结果平均取材孕周(12.12±1.31)周;穿刺成功率第一阶段68.42%,第二阶段97.65%;对过度倾屈的子宫辅助调整子宫位置后穿刺率由88.07%提高到100%;培养成功率为98.17%。未发生穿刺相关的并发症,发现异常核型4例,而终止妊娠;已分娩正常新生儿62例,继续妊娠中21例。结论孕12周左右在超声引导下经腹绒毛取材是一项安全、可行的早孕期产前诊断方法,可前移产前诊断的时间窗口。
Objective To carry out the application of transabdominal villi material in the prenatal diagnosis of early pregnancy, early prenatal diagnosis of time window. Methods In the first trimester, 125 cases of abdomen were obtained, including 38 cases of induced abortion and 87 cases of prenatal diagnosis. Results The average gestational age was (12.12 ± 1.31) weeks. The success rate of puncture was 68.42% in the first stage and 97.65% in the second stage. The puncture rate of the uterus after overpronation was increased from 88.07% to 100% The rate was 98.17%. Puncture-related complications did not occur, found in 4 cases of abnormal karyotype, and termination of pregnancy; have normal delivery of 62 newborns, 21 cases of continued pregnancy. Conclusion It is a safe and feasible method for prenatal diagnosis of early pregnancy, which can advance the time window of prenatal diagnosis.