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阿斯匹林性哮喘亦名阿斯匹林诱发的哮喘、解热镇痛药哮喘,合并鼻息肉。鼻窦炎者称为阿斯匹林哮喘综合征,约占哮喘病人的1/5～1/3。病因与发病机理为某些哮喘患者在眼用阿斯匹林或其他解热镇痛药、非激素类消炎药后,可抑制环加氧酶,从而抑制前列腺素特别是PGE的合成。由于此途径被封闭;合成前列腺素的原料花生四烯酸可在脂氧合酶的催化下生成白细胞三烯(慢反应物质),后者引起支气管强烈而持久的收缩,对环氧酶抑制的作用越强,诱发哮喘的作用越明显。
Aspirin Asthma Also known as aspirin-induced asthma, antipyretic analgesic asthma, nasal polyps merger. Sinusitis is called aspirin asthma syndrome, accounting for about 1/5 ~ 1/3 asthma patients. Etiology and pathogenesis of asthma in some patients with ophthalmic aspirin or other antipyretic analgesics, non-steroidal anti-inflammatory drugs, can inhibit cyclooxygenase, thereby inhibiting the synthesis of prostaglandins, especially PGE. Since this pathway is blocked, arachidonic acid, a starting material for the synthesis of prostaglandins, can produce leukotrienes (slow reacting substances) catalyzed by lipoxygenases, which cause a strong and long-lasting contraction of bronchial epithelium, The stronger the role, the more obvious the role of asthma.