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原发性肝癌标志物的应用为原发性肝癌的早期诊断提供了有效的途径。而原发性肝癌的早期诊断一直是临床上的一大难题,且对其早期诊断的要求又十分迫切,这就促进了肝癌标志物的研究和应用,临床上对这些标志物的认识和评价十分重要。本文就其临床应用及其进展情况作一综述。一、甲胎蛋白甲胎蛋白(AFP)是最早发现和应用的肝痛标志物,为其早期诊断作出了重要贡献。临床观察AFP在原发性肝癌中有如下四种表现型:①持续高浓度型(浓度高且较稳定,易确诊);②持续低浓度型(虽较稳定但量少,用不敏感检测方法则易漏诊);③马鞍型(其浓度曲线呈马鞍状,如在低峰期用不敏感检测方法也易漏诊);④阴性型(在国
The application of markers of primary liver cancer provides an effective approach for the early diagnosis of primary liver cancer. The early diagnosis of primary liver cancer has always been a major clinical problem, and the requirements for its early diagnosis are very urgent. This promotes the research and application of liver cancer markers, and the clinical understanding and evaluation of these markers. Very important. This article reviews its clinical application and its progress. First, alpha-fetoprotein alpha-fetoprotein (AFP) is the earliest discovered and applied marker of liver pain, making an important contribution to its early diagnosis. Clinical observation AFP in the primary liver cancer has the following four phenotypes: 1 continuous high-concentration type (high and stable, easy diagnosis); 2 continuous low-concentration type (although more stable but less, use insensitive detection methods Easy to miss diagnosis); 3 saddle type (its concentration curve is saddle-shaped, such as insensitive detection method is also easy to miss in the low peak period); 4 negative type (in the country