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已知东莨菪碱可预防晕动症,但针片剂有口渴、睫状肌麻痹、思睡等副作用。作者将东莨菪碱透皮治疗体系(TTS),以耳后贴药方法(大小如分币),与口服茶苯海明(D)及安慰剂(P)作对照。受试者随机分为四组,分别在不同大小的海浪中进行快艇海洋运动测验。TTS在海洋运动试验前的4～16小时给药贴于耳后,余两药在试验前1.5小时及试验开始后2.5小时各口服一次。
Known scopolamine can prevent motion sickness, but needle tablets have thirst, cycloplegia, sleepiness and other side effects. The authors compare the transdermal delivery system (TTS) of scopolamine to oral administration of cefotidime (D) and placebo (P) in an ear posterior patch size (in centuries). Subjects were randomly divided into four groups, respectively, in different sizes of the waves in the speedboat marine exercise test. TTS in the 4 to 16 hours before the marine exercise test is applied to the ear, the remaining two drugs 1.5 hours before the test and 2.5 hours after the start of each oral test.