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痴呆常见于艾滋病(AIDS)病人,但对人免疫缺损病毒1型(HIV-I)引起神经破坏的机制尚不清楚。本研究是检测HIV-Ⅰ抗原抑制神经元对神经营养性因子的反应的可能性。HIV-Ⅰ和相关的逆转录病毒猿猴免疫缺陷病毒(SIV)都抑制含神经白细胞素(NLK)培养基中的鸡背根神经节的感觉神经元生长,但不抑制含神经
Dementia is common in AIDS patients, but the mechanism by which human immunodeficiency virus type 1 (HIV-I) causes nerve damage is not known. This study examined the potential of HIV-I antigens to inhibit neuronal responses to neurotrophic factors. Both HIV-I and the associated retrovirus simian immunodeficiency virus (SIV) inhibit the growth of sensory neurons in the dorsal root ganglion (DRG) in neuronal leukocyte (NLK) -containing media but do not inhibit neuronal growth