内分泌治疗是雌激素受体(ER)阳性乳腺癌治疗的重要手段之一。临床研究显示,许多接受内分泌治疗的患者在治疗期间或治疗后发生复发,这些患者对内分泌治疗原发耐药或在治疗期间发生耐药。因此,有必要寻找可靠预测因子来预测哪些患者对内分泌治疗敏感。本文主要探讨临床病理因素、多基因检测及液体活检在乳腺癌内分泌治疗中的预测作用。 Endocrine therapy is an important means of treatment of estrogen receptor (ER) -positive breast cancer. Clinical studies have shown that many patients receiving endocrine therapy relapse during or after treatment with either endocrine therapy primary resistance or resistance during treatment. Therefore, it is necessary to find reliable predictors to predict which patients are sensitive to endocrine therapy. This article focuses on the clinical and pathological factors, multi-gene testing and liquid biopsy in the predictive value of breast cancer endocrine therapy.