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盐酸纳洛酮(Naloxone hydrochloride,NLX)为阿片受体拮抗剂,可竞争性地阻滞并取代阿片样物质与受体的结合,临床用于治疗阿片类中毒及应用于麻醉剂与非麻醉剂过量、休克、婴儿窒息、急性乙醇中毒、脑血管病等应激状态,用以拮抗体内β-内啡肽(β-EP)增多而引起的中枢神经系统抑制。自Baskin等报道纳洛酮有恢复脑缺血的作用以来,国内外的相继报道不少。但在纳洛酮对心源性脑梗死的治疗目前尚无文献报道。本文应用该药治疗心源性脑梗死17例,对其疗效、安全性、用药剂量及疗程作如下探讨。
Naloxone hydrochloride (NLX), an opioid receptor antagonist, competitively blocks and replaces the combination of opioid and receptor. It is clinically used to treat opioidosis and is used in overdose and non- Shock, infantile asphyxia, acute alcoholism, cerebrovascular disease and other stress states, to antagonize the increase in body β-endorphin (β-EP) caused by the central nervous system depression. Since Baskin et al reported that naloxone has the role of restoring cerebral ischemia, many have been reported at home and abroad. However, naloxone in the treatment of cardio-cerebral infarction is currently no literature. In this paper, the drug treatment of cardiac cerebral infarction in 17 cases, its efficacy, safety, dosage and course of treatment as follows.