肝癌是我国常见恶性肿瘤之一。近十多年来应用甲种胎儿蛋白(AFP)诊断原发性肝细胞肝癌是一个有效的指标,但仍存在一定的局限性,约有15—20％AFP阴性或低水平AFP,以及胆管细胞肝癌和转移性肝癌仍缺乏特异性的肝癌标志物,因而有必要寻找其它肿瘤标志物来弥补其不足。胰蛋白酶抑制剂(α_1-Antitrypsin简称A_1AT)是一种分子量约54,000的糖蛋白,由肝脏合成和分解代谢的一种重要的血清蛋白酶抑制 Liver cancer is one of the most common malignancies in China. The use of alpha-fetoprotein (AFP) in the diagnosis of primary hepatocellular carcinoma in the past decade is an effective indicator, but there are still some limitations, about 15-20% of AFP-negative or low-level AFP, and bile duct cells Liver cancer and metastatic liver cancer still lack specific markers of liver cancer, so it is necessary to find other tumor markers to make up for their deficiencies. Tryptase inhibitor (α_1-Antitrypsin referred to as A_1AT) is a glycoprotein with a molecular weight of about 54,000, an important serum protease inhibitor that is synthesized and catabolized by the liver.