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目的:探讨阿昔洛韦致急性肾功能损害特点、相关因素及预防措施,为临床用药提供参考。方法:查阅阿昔洛韦致急性肾功能损害有关文献36篇(共84例),对病例的资料进行整理,统计与归纳。结果:阿昔洛韦所致的急性肾功损害在不同的年龄段均可发生,在男性患者中出现的例数比女性高,短时间、高浓度、大剂量静脉滴注及在用药后没有按时给予足够量的水化是产生肾功能损害的主要诱因,其治疗预后良好。结论:临床医师、药师应重视发现异常应立即停药,并尽快明确诊断,及时给予对症治疗。
Objective: To investigate the characteristics, related factors and preventive measures of acyclovir-induced acute renal dysfunction and provide references for clinical use. Methods: Acyclovir-induced acute renal damage related to the literature 36 (84 cases), the case data were collated, statistics and summarized. RESULTS: Acute renal impairment caused by acyclovir occurred in different age groups. The incidence of acyclovir in the male patients was higher than that in the female patients. Short-term, high-concentration, high-dose intravenous drip and no Adequate hydration on time is the main cause of impaired renal function and its prognosis is good. Conclusion: Clinicians and pharmacists should attach great importance to discovering abnormalities immediately and stop diagnosing as soon as possible, and make diagnosis as soon as possible and timely give symptomatic treatment.