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目的:检测重症肝炎患者血清中PGs代谢产物的水平,探讨COX-2与重症肝炎的关系,进一步指导临床对重症肝炎的预测及治疗。方法:采用双抗体夹心ELISA法检测50例重症肝炎患者和25例正常对照血清中PGs代谢产物TXB2、6ketoPGF1α的水平。结果:急性,亚急性和慢性重症肝炎患者血清TXB2和6-keto-PGF1α及T/K的表达水平均明显高于对照组(P<0.01),急性、亚急性和慢性重症肝炎患者各组TXB2和6ketoPGF1α的表达水平无统计学差异。结论:COX-2在重症肝炎的发生发展中起着一定的作用,检测重症肝炎患者血清TXB2、6-keto-PGF1α的水平和T/6-K比值对监测重症肝炎患者病情转归和预后有重要临床意义。
Objective: To detect the serum levels of PGs metabolites in patients with severe hepatitis and to explore the relationship between COX-2 and severe hepatitis, to further guide the clinical prediction and treatment of severe hepatitis. Methods: Double antibody sandwich ELISA was used to detect the levels of TXB2 and 6ketoPGF1α in 50 patients with severe hepatitis and 25 normal controls. Results: The levels of TXB2 and 6-keto-PGF1α and T / K in acute, subacute and chronic severe hepatitis patients were significantly higher than those in control group (P <0.01). The levels of TXB2 And 6ketoPGF1α expression levels were not statistically different. Conclusions: COX-2 plays a role in the occurrence and development of severe hepatitis. To detect the serum levels of TXB2, 6-keto-PGF1α and the ratio of T / 6-K in patients with severe hepatitis to monitor the prognosis of patients with severe hepatitis Important clinical significance.