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目的:观察健脾通络方对早期糖尿病肾病(DN)微量白尿蛋白排泄率的影响。方法:将入选患者70例随机分为两组,每组各35例。两组均在常规治疗基础上,治疗组予健脾通络方合缬沙坦胶囊;对照组予缬沙坦胶囊,疗程12周,观察治疗前后尿微量白蛋白排泄率(UAER)、尿β2微球蛋白(尿β2-GM)、平均动脉压(MAP)、肝肾功能、心电图。结果:治疗组总有效率优越于对照组,有显著性差异(P<0.01)。结论:健脾通络方合缬沙坦胶囊对早期DN有很好的保护作用。
Objective: To observe the effects of Jianpi Tongluo Prescription on microalbuminuria excretion rate in patients with early diabetic nephropathy (DN). Methods: The selected patients were randomly divided into two groups of 70 patients, 35 cases in each group. The two groups were on the basis of routine treatment, the treatment group was treated with spleen and collaterals Valsartan capsules; the control group was given valsartan capsules for 12 weeks, the urinary albumin excretion rate (UAER), urinary β2 Microglobulin (urinary β2-GM), mean arterial pressure (MAP), liver and kidney function, electrocardiogram. Results: The total effective rate in the treatment group was superior to that in the control group, with significant difference (P <0.01). Conclusion: Jianpi Tongluo combined valsartan capsule has a good protective effect on early DN.