用光镜、电镜及免疫组化方法，动态观察了大鼠经胸部照射３０Ｇｙ后肺组织内纤维连接蛋白（ＦＮ）和层粘连蛋白（ＬＮ）的变化。结果显示，照射组大鼠肺组织内ＦＮ、ＬＮ分布紊乱，ＦＮ含量在病变早期较明显增多，而病变后期则逐渐减少；ＬＮ在各期均有不同程度增加。提示，ＦＮ主要参与放射性肺损伤早期病变的发生发展；ＬＮ参与肺损伤病变的全过程。 The changes of fibronectin (FN) and laminin (LN) in the lung tissue of rats were observed dynamically by light microscope, electron microscope and immunohistochemical method after 30 Gy of thoracic irradiation. The results showed that the distribution of FN and LN in the lung tissue of the irradiated group was disordered. The content of FN in the irradiated group was significantly increased in the early stage of the lesion and gradually decreased in the late stage of the lesion. The LN increased at different stages in different stages. Tip, FN mainly involved in the development of early lesions of radiation-induced lung injury; LN involved in the whole process of lung injury.