本实验采用SD大鼠56只,于顶皮质作一宽2mm的冠状切口,用尼氏染色和AchE阳性纤维染色,观察损伤后胰岛素对切口两侧胶质细胞变化的影响.结果:损伤组和损伤用药组损伤切口两侧的胶质细胞在1～2W内迅速增生和集聚;2～3W出现胶质瘢痕,4～8W内增生的胶质细胞减少,胶质瘢痕收缩成一条致密带,再生胆碱能纤维沿切口两侧生长,难以穿越瘢痕组织,胰岛素用药组皮质损伤切口两侧的胶质细胞增生虽较损伤组轻,但还不足以有效的抑制胶质瘢痕的形成. In this study, 56 SD rats were used to make a 2 mm wide coronal incision on the parietal cortex, and Nissl staining and AchE positive staining were used to observe the effects of insulins on the changes of glial cells on both sides of incision.Results: Injured the wounds on both sides of the injury group glial cells in 1 ~ 2W rapid proliferation and accumulation; 2 ~ 3W glial scar, 4 ~ 8W glial cells within the proliferation decreased glial scar contraction into a dense zone, regeneration Cholinergic fibers grow along both sides of the incision, it is difficult to cross the scar tissue, insulin treatment group cortical injury on both sides of the glial cell proliferation than the injury group, but not enough to effectively inhibit the formation of glial scar.