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动物实验已证明,黄体生成素释放激素(LH-RH)具有延迟交配和阴道角化的作用以及交配后的避孕作用。至少在大鼠,LH-RH及其高活性类似物的这一抗生育作用是由于溶黄体并伴有卵巢LH、FSH和生乳素受体的明显丧失以及血浆孕酮水平的下降。作者试图研究在正常妇女的黄体期使用LH-RH是否有溶黄体作用。选择10例26～42岁的健康妇女作为受试者。其月经周期规则,无内分泌或妇科疾患,并在6个月内未用口服避孕药。至少连续观察3个治疗周期。分别于排卵后的1至9天间开始用LH-RH,于晨8时第一次用药,然后在1天或连续2天内,每4小时用药1次,共用药5次,每次均为皮下注射250
Animal experiments have shown that luteinizing hormone-releasing hormone (LH-RH) has the effect of delayed mating and vaginal keratosis and contraception after mating. This anti-fertility effect of LH-RH and its hyperactive analogs, at least in rats, is due to the significant loss of the corpus luteum accompanied by ovarian LH, FSH and lactogen receptors and a decrease in plasma progesterone levels. The authors attempted to investigate whether the use of LH-RH during the luteal phase of normal women had a corpora lutea effect. Ten healthy women aged from 26 to 42 were selected as subjects. Its menstrual cycle rules, no endocrine or gynecological disorders, and within 6 months without oral contraceptives. At least 3 consecutive treatment cycles were observed. LH-RH was started at 1 to 9 days after ovulation, the first time at 8:00 AM and then once every 4 hours for 1 day or 2 consecutive days for a total of 5 times, each time being Subcutaneous injection 250