咪康唑为咪唑类抗真菌药,对许多临床致病真菌如白色念菌珠、新生隐球菌、芽生菌、球孢子菌和一些表皮真菌都有良好的抗菌作用,国内外咪康唑制剂有注射剂、霜剂、栓剂和甘油剂。由于咪康唑在醇中溶解度较小,饱和溶液不能满足临床需要。为此,我们选用苯甲酸钠为助溶剂制成2%的咪康唑擦剂,提高了制剂的溶解度和疗效。但苯甲酸干扰了咪康唑的含量测定,为此,我们建立了HPL测定其含量,结果满意,现报道如下: Miconazole is an imidazole antifungal agent that has good antibacterial activity against many clinically pathogenic fungi such as Candida albicans, Cryptococcus neoformans, Blastomyces, Coccidioidomycosis and some epidermal fungi. Micronazole preparations at home and abroad Injection, cream, suppository and glycerin. Due to the low solubility of miconazole in alcohol, the saturated solution can not meet the clinical needs. To this end, we use sodium benzoate as a cosolvent to make 2% miconazole liniment to improve the solubility and efficacy of the preparation. But benzoic acid interfere with the determination of miconazole, therefore, we established the HPL determination of its content, the results are satisfactory, are reported as follows: