The behavior and fates of environmental pollutants within the cryosphere and the associated environmental impacts are of increasing concerns in the context of global warming. The Tibetan Plateau (TP), also known as the “Third Pole”, repre-sents one of the most important cryospheric regions in the world. Mercury (Hg) is recognized as a global pollutant. Here, we summarize the current knowledge of Hg concentration levels, pools and spatio-temporal distribution in cryospheric en-vironments (e. g., glacier, permafrost), and its transfer and potential cycle in the TP cryospheric region. Transboundary transport of anthropogenic Hg from the surrounding heavily-polluted regions, such as South and Southeast Asia, provides significant sources of atmospheric Hg depositions onto the TP cryosphere. We concluded that the melting of the cryo-sphere on the TP represents an increasing source of Hg and brings a risk to the TP environment. In addition, global warm-ing acts as an important catalyst accelerating the release of legacy Hg from the melting cryosphere, adversely impacting ecosystems and biological health. Furthermore, we emphasize on the remaining gaps and proposed issues needed to be ad-dressed in future work, including enhancing our knowledge on some key release pathways and the related environmental effects of Hg in the cryospheric region, integrated observation and consideration of Hg distribution, migration and cycle processes at a key region, and uses of Hg isotopic technical and Hg models to improve the understanding of Hg cycling in the TP cryospheric region.