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本文报告1例可能是由于灰黄霉素引起的SLE致死性恶化。患者女性,22岁患SLE 6年,此次因发热,出汗及不适一月而入院。SLE诊断是基于发热、淋巴结肿大、雷诺氏现象,指(趾)血管炎,光敏和蝶形红斑。ANA和dsDNA抗体阳性。以后出现蛋白尿,肾活捡示局灶性增殖性肾小球肾炎;脑电图显示有弥漫性慢波。以强的松龙隔日7mg维持治疗。入院前一个多月,因怀疑呼吸道感染而用过氨苄青霉素和红霉索,入院前7天曾服过灰黄霉素,虽然准确剂量不详,但总剂量不超过
This article reports 1 case may be due to griseofulvin-induced lethal deterioration of SLE. Female patient, 22 years old suffering from SLE 6 years, the fever, sweating and discomfort in January and admission. SLE diagnosis is based on fever, swollen lymph nodes, Raynaud’s phenomenon, finger vasculitis, light sensitivity and butterfly erythema. ANA and dsDNA antibody positive. After proteinuria, renal biopsy showed focal proliferative glomerulonephritis; EEG showed diffuse slow wave. Maintain treatment with prednisolone 7mg every other day. More than a month before admission, ampicillin and erythromycin had been used for suspected respiratory infections and griseofulvin had been taken seven days before admission. Although the exact dose was unknown, the total dose did not exceed