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肾血流(RBP)减少在肾缺血性疾病和急性肾衰(ARF)过程中是很常出现的一种血流动力学改变。肾血流减少与肾缺血是同义词。缺血引起的组织损伤,不仅仅是发生在缺氧(或低氧)期,而在缺血后血流恢复期(即再灌流期或再循环期)也可引起组织损伤,这称为再灌流损伤。在某些临床情况下,缺血缺氧的损伤主要不是发生在缺血期间,而是发生在再灌流时(即在输血输氧,分子氧重新进入组织时)。肾脏是对缺血和再灌流损伤非常敏感的器官,肾缺血时肾组织的损伤作用及其在ARF的发生中所占的重要地位日益受到人们的关注。本文介绍ARF时RBF减少的实验性研究以及肾缺血在肾组织和ARF中的重要作用。一、ARF时RBF的变化ARF时RBF变化的资料很多是来自动物ARF模型,在动物身上复制ARF模型有多种
Renal blood flow (RBP) reduction is a frequent haemodynamic change in renal ischemic disease and acute renal failure (ARF). Renal blood flow reduction is synonymous with renal ischemia. Ischemia-induced tissue damage occurs not only in the hypoxic (or hypoxic) phase, but also in the post-ischemic recovery (ie, reperfusion or recycle), which is called Perfusion injury. In some clinical settings, ischemia and hypoxia do not occur mainly during ischemia, but rather during reperfusion (ie during transfusions and reoxygenation of tissue oxygen). The kidney is an organ that is very sensitive to ischemia and reperfusion injury. The renal damage caused by renal ischemia and its importance in the occurrence of ARF are attracting more and more attention. This article describes the experimental study of RBF reduction in ARF and the important role of renal ischemia in renal and ARF. First, the ARF changes in RBF ARF RBF changes in the lot of information from the animal ARF model, ARF models in animals to copy a variety of