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目的应用观察卡铂-平阳霉素加放疗同期治疗晚期口腔癌的疗效。方法 83例晚期口腔癌患者随机分为治疗组和对照组,治疗组每天用平阳霉素16mg,隔日1次,共计200mg,疗程14d。化疗后采用直线加速器放射治疗,每次2GY,照射总量为60-70GY。对照组化疗同治疗组。结果治疗组和对照组在化疗14d及半年后观察,颈淋巴结消退率分别为30.61%、26.47%和79.80%、73.52%(P<0.05)。结论卡铂-平阳霉素化疗同期放疗,有利于提高晚期口腔癌患者淋巴结转移灶消减,提高生存率,是治疗晚期口腔癌有效的方法之一。
Objective To observe the curative effect of carboplatin-pingyangmycin plus radiotherapy in the treatment of advanced oral cancer. Methods Eighty-three patients with advanced oral cancer were randomly divided into treatment group and control group. The treatment group received Pingyangmycin 16mg every other day, once every other day for a total of 200mg for 14 days. After chemotherapy using linear accelerator radiation therapy, each 2GY, the total irradiation of 60-70GY. Control group chemotherapy with the treatment group. Results The treatment group and control group were observed on the 14th and 6th months after chemotherapy. The regression rates of cervical lymph nodes were 30.61%, 26.47% and 79.80%, 73.52% (P <0.05) respectively. Conclusions Concurrent radiotherapy with carboplatin and pingyangmycin is helpful to reduce the lymph node metastasis and improve the survival rate of patients with advanced oral cancer, which is an effective method for the treatment of advanced oral cancer.