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本文用试管内复活的HSV-1模型研究了CC和ACV对小鼠三叉神经节内潜伏HSV的作用。实验显示CC 10μg/ml和ACV 2.5μg/ml对潜伏病毒复活有明显抑制作用,CC 25μg/ml能达到与ACV 10μg/ml相当的作用强度,但在除去药物后其作用的维持时间不如ACV长。持续提供药物可以阻止潜伏病毒在试管内复活,即使采用间断给药方法亦不能完全排除潜伏病毒,但可以显著降低神经节内病毒滴度。二药联合应用对抑制潜伏病毒复活有协同作用。
In this study, we investigated the effects of CC and ACV on latent HSV in the trigeminal ganglia of mice by HSV-1 model in vitro. The experimental results showed that CC 10μg / ml and ACV 2.5μg / ml could significantly inhibit the resuscitation of latent virus, while CC 25μg / ml could achieve the same effect intensity as ACV 10μg / ml, but the effect was not as long as ACV after removing drug . Continuous drug delivery prevented the latent virus from resurging in vitro. Even intermittent dosing did not completely eliminate the latent virus, but significantly reduced the virus titer in the ganglia. The combination of two drugs have a synergistic effect on inhibiting the revival of latent virus.