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本研究采用X线全身照射昆明系雄性小鼠模型,观察电离辐射诱导免疫适应性反应的预照射剂量(D1剂量,75mGy)及其后损伤性剂量(D2剂量,1.5~2.0Gy)的时间效应。结果表明,D1与D2时间间隔6~48h,D2照后18~24h可诱导胸腺细胞自发增殖能力及脾细胞对丝裂原(ConA和LpPS)反应性等适应性反应。
In this study, we used X-ray whole body irradiation to observe the pre-irradiation dose (D1 dose, 75mGy) and subsequent injury dose (D2 dose, 1.5 ~ 2.0Gy) of Kunming mice induced by ionizing radiation. The time effect. The results showed that the adaptive response of thymocytes to spontaneous proliferation of thymocytes and the reactivity of spleen cells to mitogen (ConA and LpPS) was observed in 6 ~ 48h intervals of D1 and D2 and 18 ~ 24h after D2 irradiation.