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目的了解沙利度胺对白塞病黏膜损害的疗效。方法对2002年1月-2008年12月间61例白塞病患者的临床资料进行回顾性研究,所有纳入患者均无重要内脏器官的损害。沙利度胺治疗剂量100 mg/d,治疗疗程12周,以后逐步减量。结果 48例完全缓解(在治疗期间无口腔及外生殖器溃疡),但停药后溃疡复发。7例出现上下肢体麻木感,停药后麻木感消失。结论沙利度胺对白塞病的口腔及外生殖器溃疡治疗有效,100 mg/d的治疗剂量合适。
Objective To understand the curative effect of thalidomide on Behçet’s disease. Methods The clinical data of 61 patients with Behcet’s disease from January 2002 to December 2008 were retrospectively studied. All the patients were enrolled in the study without any significant internal organ damage. Thalidomide dose of 100 mg / d, the course of treatment for 12 weeks, then gradually reduced. Results 48 cases of complete remission (no oral and genital ulcers during treatment), but the ulcer recurrence after drug withdrawal. 7 cases of upper and lower body numbness, numbness after treatment disappeared. Conclusions Thalidomide is effective in the treatment of oral and external genital ulcers in Behcet’s disease with a suitable dose of 100 mg / d.