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注射羊抗兔肾血清制造肾小球肾炎模型中发现:(1)如抗肾血清有溶血现象(当用兔新鲜红细胞吸附时造成的溶血),可增加动物的死亡率。一次注射抗肾血清复制动物产生明显蛋白尿的成功率为61％。(2)尿蛋白的多少可以反映病理改变的程度,但尿蛋白少于“++”,在光镜下常不能见到明显改变,而电镜下可见上皮足突融合和电子致密物沉积于显著增厚的基膜上。(3)血胆固醇、尿素氮和血肌酐的水平与病理改变的严重程度密切相关。
Injection of goat anti-rabbit serum in the manufacture of glomerulonephritis model found: (1) such as anti-renal serum hemolysis (when using fresh red blood cells adsorbed when the hemolysis), can increase animal mortality. One injection of anti-renal serum in animals produced significant proteinuria with a success rate of 61%. (2) The number of urinary protein can reflect the degree of pathological changes, but the urinary protein less than “++”, often can not see the obvious change under the light microscope, while electron microscopy shows epithelial foot process fusion and electronic dense deposition in significant Thickening of the basement membrane. (3) The levels of blood cholesterol, urea nitrogen and serum creatinine are closely related to the severity of pathological changes.