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目的探讨血清肾上腺髓质素及内皮素在鲍曼不动杆菌(AB)医院获得性肺炎患者血浆中含量的变化及临床意义。方法采用ELISA法测定30例AB医院获得性肺炎患者(研究组)和60例健康体检者(对照组)血清中肾上腺髓质素(ADM)的含量。结果研究组血浆ADM为(65.4±18.7)ng/ml,对照组为(32.0±8.7)ng/ml,差异有统计学意义(t=8.85,P<0.01)。研究组血浆ET-1为(105.6±16.6)ng/ml,对照组为(79.7±5.6)ng/ml,差异有统计学意义(t=6.73,P<0.01)。结论 ET及ADM在鲍曼不动杆菌医院获得性肺炎患者血浆中有明显升高,ADM可能在气道保护及抗感染方面起重要作用。
Objective To investigate the changes of plasma levels of serum adrenomedullin and endothelin in patients with Acinetobacter baumannii (AB) hospital acquired pneumonia and its clinical significance. Methods Serum levels of adrenomedullin (ADM) were measured in 30 patients with AB hospital acquired pneumonia (study group) and 60 healthy controls (control group) by ELISA. Results The plasma ADM level was (65.4 ± 18.7) ng / ml in the study group and (32.0 ± 8.7) ng / ml in the control group, the difference was statistically significant (t = 8.85, P <0.01). The ET-1 level in the study group was (105.6 ± 16.6) ng / ml and that in the control group was (79.7 ± 5.6) ng / ml, the difference was statistically significant (t = 6.73, P <0.01). Conclusion ET and ADM in plasma of patients with Acinetobacter baumannii hospital acquired pneumonia were significantly increased, ADM may play an important role in airway protection and anti-infective.