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目的:研究肾移植术后微小病毒B19感染的情况。方法:采用间接ELISA的方法检测肾移植术后患者血清标本中抗微小病毒-B19(HPV-B19)IgM和IgG抗体的浓度,并与肾移植前及健康献血员进行比较。结果:肾移植后患者血清标本中HPV-B19IgM抗体的浓度和阳性率明显高于肾移植前和健康对照,而HPV-B19IgG抗体无明显改变。结论:肾移植术后,机体免疫力下降,HPV-B19感染的机率上升,可能引起以贫血为主的多系统多器官的功能障碍,影响肾移植的效果。
Objective: To investigate the infection of parvovirus B19 after renal transplantation. Methods: The serum anti-parvovirus-B19 (HPV-B19) IgM and IgG antibody levels in renal transplant recipients were measured by indirect ELISA and compared with those before kidney transplantation and healthy blood donors. Results: The concentration and positive rate of HPV-B19 IgG antibody in serum of patients after kidney transplantation were significantly higher than those before kidney transplantation and healthy controls, while the antibody of HPV-B19 IgG did not change significantly. Conclusion: After the kidney transplantation, the immunity of the human body is decreased and the infection rate of HPV-B19 is increased. It may cause the anemia-dominated multi-system and multi-organ dysfunction and affect the renal transplantation.