娠妊期感染乙型肝炎病毒的不良影响,如多次发生自发性流产和死胎,过去已有报导。但是,母亲患病毒性肝炎与生出先天愚型患儿的关系,现仍不清楚。有人报告,娠妊期罹患另一种慢病毒感染——风疹,与先天愚型的发生率增高和性染色体异常有关。本文报告2例新生儿染色体异常,其母在娠妊期曾受乙型肝炎病毒的感染。例1 女婴,32周早产,出生体重1,680g,母亲在娠妊5个月后两次查HBsAg阳性,e抗原阴性,否认有药物及酒精嗜好,曾娩一正常男婴。患儿生后窒息,经抢救1S分钟后恢复自主呼吸。体检时发现有急性呼吸道疾病,两耳低位,眼裂向外上斜,两眼内 The adverse effects of hepatitis B virus infection during pregnancy and pregnancy, such as multiple spontaneous abortion and stillbirth, have been reported in the past. However, the relationship between mother’s viral hepatitis and children with Down’s syndrome is still unclear. Some people report that another lentivirus infection during pregnancy and pregnancy-rubella-is associated with an increased incidence of idiopathic obesity and sex chromosome abnormalities. This article reports 2 cases of neonatal chromosomal abnormalities, the mother had hepatitis B virus infection during pregnancy. Example 1 Baby girl, 32 weeks premature birth, birth weight 1,680g, mother 5 months after pregnancy, pregnancy twice HBsAg positive, e antigen negative, denied the presence of drugs and alcohol, had given birth to a normal baby boy. Children with asphyxia after birth, rescue 1S minutes after resuming spontaneous breathing. Physical examination found that acute respiratory diseases, both ears low, eye split outward oblique, both eyes