导言在动脉血栓性疾病的病理过程中，血小板活化是重要的始动因素。有许多物质，如凝血酶、肾上腺素等可导致血小板的活化和聚集。近年来研究发现，血流中单纯的高剪切应力也可以诱导血小板聚集。这不但对于存在高剪切应力的血管，如小动脉，动脉痉挛和动脉硬化造成的局部狭窄 Introduction Platelet activation is an important initiating factor in the pathogenesis of arterial thrombotic disorders. There are many substances, such as thrombin, epinephrine, etc. can lead to platelet activation and aggregation. In recent years, studies have found that high shear stress in the bloodstream can also induce platelet aggregation. This is not only for the existence of high shear stress of blood vessels, such as arterioles, arterial spasm and atherosclerosis caused by local stenosis