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梗塞部位的心肌发生间质水肿,而阻碍了营养物质的供应和有害物质的清除,尤其组织压的上升,促进微循环功能不全。酸性粘多醣是梗塞部位细胞间质的主要成份,其中有从间质细胞分泌的透明质酸,是一种不规则的盘绕状分子结构,亲水性极强,且低浓度溶液也具有阻滞高分子物质扩散的特性,因此在急性心肌梗塞时用透明质酸酶(GL enz)来分解透明质酸,以保护梗塞部位的心肌,有可能是缩小梗塞面积的一种有效治疗方法。对此,自1959年以来就有很多的研究。当初这种效果的研究,主要是用鼠和犬进行动物实验。很多报告表明,透明质酸酶对梗塞部位的
Myocardial infarction myocardial interstitial edema, which hindered the supply of nutrients and the removal of harmful substances, especially the rise in tissue pressure and promote microcirculation insufficiency. Acid mucopolysaccharide is the main component of the interstitial cells in the infarction area. Among them, hyaluronic acid secreted from interstitial cells is an irregular coiled molecular structure with strong hydrophilicity and low concentration solution. Therefore, in the case of acute myocardial infarction, hyaluronan (GLenz) is used to decompose hyaluronic acid to protect myocardium at the infarct site, which may be an effective method to reduce infarct size. In this regard, there have been many studies since 1959. The original study of this effect, mainly animal experiments with mice and dogs. Many reports indicate that hyaluronidase is on the infarct site