改善肿瘤细胞的乏氧,可有效减少其对放疗的抵抗,从而提高治愈率。目前用于改善肿瘤细胞缺氧减少放射抵抗的化合物已经不仅仅局限于原有的亲电性放射增敏剂,许多具有靶向性的乏氧放射增敏剂也成为研究重点。本文在介绍肿瘤乏氧机制的基础上,对新型靶向制剂、亲电性乏氧细胞放射增敏剂、生物还原剂与植物天然提取物这四类乏氧细胞放射增敏剂的研究进展进行了综述。 Improve the hypoxia of tumor cells, which can effectively reduce its resistance to radiotherapy to improve the cure rate. At present, the compounds that are used to improve the radioresistance of tumor cells to hypoxia decrease have not only limited to the original electrophilic radiosensitizers, but many targeted hypoxia radiosensitizers have also become the focus of research. Based on the introduction of tumor hypoxia mechanism, the progress of the research on four types of hypoxic cell radiosensitizers, which are new targeted agents, electrophilic hypoxic cell radiosensitizers, biological reducing agents and plant natural extracts, is carried out A review