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目的探讨左旋甲状腺素钠片治疗原发性甲状腺功能减退症合并垂体增生患者的效果。方法选取2012年2月至2016年4月中山大学附属东华医院收治的80例原发性甲状腺功能减退症合并垂体增生患者作为研究对象,按照随机数字表法将其分为观察组和对照组,各40例。对照组患者给予左甲状腺素钠片,观察组患者采用左旋甲状腺素钠片进行治疗,比较两组患者甲状腺功能、血脂水平、心肌酶谱指标、治疗满意度及垂体增生情况。结果两组患者在甲状腺功能及血脂指标方面比较,观察组明显优于对照组,差异有统计学意义(P<0.05);观察组与对照组患者在心肌酶谱指标方面比较,观察组优于对照组,差异有统计学意义(P<0.05);观察组患者的治疗满意度明显高于对照组,差异有统计学意义(P<0.05);观察组患者的垂体改善效果明显优于对照组,差异有统计学意义(P<0.05)。结论左旋甲状腺素钠片治疗原发性甲状腺功能减退症合并垂体增生临床效果显著。
Objective To investigate the effect of levothyroxine sodium tablets in patients with primary hypothyroidism complicated with pituitary hyperplasia. Methods Eighty patients with primary hypothyroidism complicated with pituitary hyperplasia admitted from Donghua Hospital Affiliated to Sun Yat-sen University from February 2012 to April 2016 were selected as the research subjects and divided into observation group and control group according to the random number table , 40 cases each. Patients in the control group were given levothyroxine sodium tablets. Patients in the observation group were treated with levothyroxine sodium tablets. Thyroid function, blood lipid levels, myocardial enzymes, treatment satisfaction and pituitary hyperplasia were compared between the two groups. Results The two groups of patients in thyroid function and blood lipid indicators, the observation group was significantly better than the control group, the difference was statistically significant (P <0.05); the observation group and the control group patients in myocardial enzyme parameters, the observation group was better than (P <0.05). The treatment satisfaction of patients in the observation group was significantly higher than that of the control group (P <0.05), and the improvement effect of the pituitary in the observation group was obviously better than that of the control group , The difference was statistically significant (P <0.05). Conclusion L-thyroxine sodium tablets treatment of primary hypothyroidism with pituitary hyperplasia clinically significant effect.