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用单克隆抗体技术测定了16例病程在1.5年以上的IDDM患者和18例正常人外周血总T淋巴细胞及其亚群,显示两组间OKT_3、OKT_4、OKT_8、OKT_4/OKT_8差异均无显著性。提示病程超过1.5年的IDDM者的细胞免疫功能已趋于稳定。且16例IDDM患者的总T淋巴细胞及其亚群在胰岛移植前、后差异也没有显著性,认为目前国内应用的胡氏胰岛组织培养法有利于降低胰岛组织对人IDDM受体的免疫原性。
16 cases of IDDM patients with more than 1.5 years of history and 18 cases of normal human peripheral blood total T lymphocytes and their subpopulations were determined by monoclonal antibody technique. There was no significant difference in OKT_3, OKT_4, OKT_8, OKT_4 / OKT_8 between the two groups Sex. It is suggested that the cellular immune function of IDDM patients whose disease duration is more than 1.5 years has tended to be stable. And 16 cases of IDDM patients with total T lymphocytes and its subgroup in the islet transplantation before and after the difference was not significant, that the current domestic application of islet islet tissue culture is conducive to reduce the islet tissue of human IDDM receptor immunogens Sex.