Pierucei等报告了一种能改善狼疮肾炎肾功能的选择性血栓烷A_2拮抗剂。在他们的讨论中,Pierucei等指出,服用环氧合酶抑制剂后狼疮肾炎病人的肾血液动力学功能下降,不如肾小球疾病病人明显。这是由于在狼疮肾炎病人,肾血管的收缩剂血栓烷A_2的合成增加。最近在有关增生性狼疮肾炎连续病例的两项独立研究中证明,活动性肾疾病伴发肾小球滤过率的下降,但不伴发有效肾血流的减少。在某些 Pierucei et al. Reported a selective thromboxane A 2 antagonist that ameliorates renal function in patients with lupus nephritis. In their discussion, Pierucei et al. Noted that renal hemodynamics in patients with lupus nephritis following cyclooxygenase inhibitors were less pronounced than in patients with glomerular disease. This is due to the increased synthesis of thromboxane A2 in the renal vasoconstrictor in patients with lupus nephritis. Recently, in two independent studies of consecutive cases of proliferative lupus nephritis, it has been demonstrated that there is a decrease in glomerular filtration rate associated with active kidney disease but not with a decrease in effective renal blood flow. In some