红色毛癣菌菌落产生红色是该菌重要鉴定特征之一，但常遇到不产生红色的菌株。了解这种产色变异的范围和频率以及影响因素，对提高鉴定正确性、更好地指导治疗有重要意义。方法：对２００株不同地区来源的临床株进行初代分离和传代培养，并观察１％葡萄糖玉米粉吐温琼脂和马铃薯葡萄糖琼脂对产色的恢复作用；比较不同培养条件对产色变异的影响，对有关数据进行统计学处理。结果：初代产色消失率为３４％，传代诱导消失率为４９％，稳定消失率达２４％。大多数传代消失为可逆的，而大多数初代变异为不可逆的；较高的ｐＨ和较低的培养温度不利于产色。北方分离株产色消失率显著高于南方分离株。结论：红色毛癣菌产色消失率发生较高，已对其鉴定产生影响，其确切的发生机理，有待深入研究 Trichophyton rubrum colonies produce red is one of the important identification of the bacteria, but often encounter does not produce red strains. To understand the scope and frequency of chromosomal variation and its influencing factors is of great significance to improve the accuracy of identification and better guide the treatment. Methods: Primary isolation and subculture of 200 strains of clinical strains from different regions were carried out. The effects of 1% glucose and corn starch tween agar and potato dextrose agar on the recovery of production color were observed. The effects of different culture conditions on the variation of production color were compared. The data for statistical treatment. Results: The first generation of color loss rate of 34%, the pass rate of 49% disappearance, the steady disappearance rate of 24%. Most passions disappear and are reversible, while most of the primary mutations are irreversible; higher pH and lower incubation temperatures are detrimental to color production. The color loss rate of northern isolates was significantly higher than that of southern isolates. Conclusion: Trichophyton rubrum high rate of chromogenic disappearance rate, has its impact on the identification, the exact mechanism of its occurrence, pending further study