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目的:建立人血浆中布洛芬浓度的测定方法,测定布洛芬在人血浆中的蛋白结合率,并计算相关参数。方法:用平衡透析法以高效液相色谱法为检测手段测定血浆蛋白结合率。结果:布洛芬与人标准血浆的蛋白结合率为(95.4±0.3)%。结论:布洛芬与人血浆蛋白为高强度结合。
Objective: To establish a method for the determination of ibuprofen concentration in human plasma, determine the protein binding rate of ibuprofen in human plasma, and calculate the related parameters. Methods: The dialysis method was used to determine the plasma protein binding rate by high performance liquid chromatography. Results: The protein binding rate between ibuprofen and human standard plasma was (95.4 ± 0.3)%. Conclusion: Ibuprofen binds to human plasma proteins with high intensity.