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目的 探讨子宫腺肌病与卵巢异位囊肿异位内膜的细胞凋亡和增殖特性及发病机制。方法 2 0 0 2年 6月至 2 0 0 3年 6月南方医科大学珠江医院采用免疫组化S P法 ,检测子宫腺肌病 (46例 )和卵巢异位囊肿 (6 0例 )的在位及异位子宫内膜中凋亡调控基因蛋白bcl 2、bax及细胞增殖标记物Ki 6 7蛋白的表达。结果 bcl 2蛋白、bax蛋白及Ki 6 7蛋白在两症的在位内膜以及子宫腺肌病异位内膜中均呈现周期性改变 ,而bcl 2蛋白及Ki 6 7蛋白在卵巢异位囊肿异位内膜中呈持续性增强 ,较在位内膜差异有显著性意义 (P <0 0 5 )。结论 子宫腺肌病异位内膜的细胞凋亡和增殖受卵巢性激素周期性的调节 ,卵巢异位囊肿异位内膜则相反 ,两者细胞凋亡和增殖特性有着明显的不同 ,是两种不同的疾病。
Objective To investigate the apoptosis and proliferation of ectopic endometrial adenomyosis and ovarian ectopic endometrium and its pathogenesis. Methods From June 2002 to June 2003, Zhujiang Hospital of Southern Medical University used immunohistochemical SP method to detect the presence of adenomyosis (46 cases) and ovarian ectopic cysts (60 cases) And the expression of apoptosis-controlling gene protein bcl 2, bax and cell proliferation marker Ki 6 7 in ectopic endometrium. Results The bcl-2 protein, bax protein and Ki-67 protein showed periodic changes in both eutopic endometrium and adenomyosis ectopic endometrium, while bcl 2 protein and Ki 6 7 protein in ovarian ectopic cyst Ectopic endometrial showed a sustained increase, compared with the eutopic endometrium significant difference (P <0 05). Conclusions Apoptosis and proliferation of ectopic endometrium of adenomyosis are regulated periodically by ovarian hormones, and ectopic endometrium of ovarian ectopic cysts is opposite. There are obvious differences between the two groups in the apoptosis and proliferation characteristics. Different diseases.