目的对清脑宣窍方中有效部位化学成分进行系统研究。方法大孔树脂、聚酰胺、硅胶等层析方法分离,波谱法鉴定结构。结果从清脑宣窍方有效部位中分离得到9个化合物,分别为:①熊果酸,②人参皂苷Rg1,③人参皂苷Rh1(R),④人参皂苷Rh1(S),⑤人参皂苷Re,⑥人参皂苷Rb1,⑦栀子苷,⑧三七皂苷R1,⑨Genipin1Oβgentiobioside。结论以上9个化合物均为首次从复方清脑宣窍方中分离得到的已知化合物。 Objective To systematically study the chemical constituents of effective fractions in the Qingnao Xuanxiong Recipe. Methods Macroporous resins, polyamides, silica gels, etc. were separated by chromatographic methods and the structures were identified by spectral method. RESULTS: Nine compounds were isolated from the effective fraction of Qingnao Xuanxiong, which were: 1 ursolic acid, 2 ginsenoside Rg1, 3 ginsenoside Rh1(R), 4 ginsenoside Rh1(S), 5 ginsenoside Re, 6 ginsenoside Rb1, 7 geniposide, 8 notoginsenoside R1, 9Genipin1Oβgentiobioside. Conclusion The above nine compounds are all known compounds isolated from the compound Qingnaoxuanfang for the first time.