临床上常见的缺血性心脏病,如冠心病,反复发作性心绞痛,心肌梗塞等,均不可避免的引起心肌细胞不可逆性损伤。缺血引起心肌损伤的机制尚不十分清楚。近年来,国外一些科学家对缺血、特别是缺血后再灌注引起心肌损伤的机制进行了大量的研究。认为心肌损伤发生的原因除了 O_2~-自由基有害作用外,最重要的是由于 Ca~(2+)大量进入细胞内所致。因此,寻找预防或治疗这种损伤的药物,是当今急需解决的题目之一。 Common clinical ischemic heart disease, such as coronary heart disease, recurrent angina, myocardial infarction, etc., are inevitably caused by irreversible myocardial cell injury. The mechanism of myocardial damage caused by ischemia is not yet clear. In recent years, some foreign scientists have carried out a great deal of research on the mechanism of myocardial damage caused by ischemia, especially after ischemia. In addition to the harmful effects of O 2 - free radicals, the most important cause of myocardial damage is that Ca 2+ is released into the cells in large quantities. Therefore, looking for the prevention or treatment of such damage drugs, is one of the topics to be solved urgently.