巴比妥酸盐作为镇静剂应用于临床已有较久的历史,但其作为脑保护剂只始于最近20年.进入70年代以后,在动物实验上已证实了其对大脑保护作用的确切效果.最近几年,在临床上对脑梗塞所致的缺血性病变、脑外伤所致的颅内压力增高以及心脏跳动停止后的脑乏氧进行了一系列的研究,取得了较为满意的临床效果,引起人们的注意.现将最近巴比妥酸盐的有关资料及临床方面的应用问题综述如下,供参考. Barbiturates have been used clinically for more than a long time as sedatives, but only as a brain protective agent for the last 20 years, the exact effect on brain protection has been demonstrated in animal experiments since the 1970s In recent years, a series of researches on ischemic lesions caused by cerebral infarction, increased intracranial pressure caused by traumatic brain injury and hypoxic brain after cardiac arrest have been carried out clinically, and a satisfactory clinical Effect, aroused the attention of the recent barbiturates now relevant information and clinical aspects of the application are summarized below, for reference.