在成人多数正常组织中,血管生成促进因子和抑制因子处于相对平衡状态,因此血管系统也就处于相对静止状态。如果这一平衡被打破就可能导致生理性的血管生成(如伤口愈合)或病理性的血管生成(如肿瘤血管生成)。实验和临床结果均表明肿瘤自身血管系统形成是实体瘤生长和转移过程中 In most adult normal adult tissues, angiogenic promoters and inhibitors are in a state of relative balance and therefore the vasculature is at a relatively quiescent state. If this balance is broken, it may lead to physiological angiogenesis (such as wound healing) or pathological angiogenesis (such as tumor angiogenesis). Both experimental and clinical results indicate that the formation of the tumor’s own vasculature is a process of solid tumor growth and metastasis