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阿克拉霉素B(Aclacinomycin B,AcM—B)为新抗肿瘤抗生素,与亚德里亚霉素(Adriamycin)(ADM)同属葸环类抗肿瘤抗生素。ACM—B为葸环类第Ⅱ类,抑制细胞DNA相RNA合成,尤以抑制RNA的合成特别明显;ADM为第Ⅰ类,抑制DNA和RNA合成的作用程度相近。ACM-B和ADM这种抑制DNA和RNA作用的差别的机制,尚未见报道。本文就ACM—B和ADM对细胞核仁作用的特点结合大分子合成的抑制作用作一初步的比较。
Aclacinomycin B (AcM-B) is a new antitumor antibiotic and belongs to the class of antitumor antitumor antibiotics together with Adriamycin (ADM). ACM-B is a kind of 葸 ring class Ⅱ, inhibit the synthesis of DNA phase RNA, in particular inhibition of RNA synthesis was particularly evident; ADM is a class Ⅰ, inhibit the synthesis of DNA and RNA levels are similar. The mechanism by which ACM-B and ADM inhibit the difference between DNA and RNA has not been reported yet. In this paper, ACM-B and ADM on the role of the nucleolus combined with the inhibition of macromolecule synthesis for a preliminary comparison.