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目的探讨CD44V6和Bcl-2蛋白在眼睑部基底细胞癌中的表达及意义。方法选取眼科2000年至2010年手术切除眼睑部基底细胞癌的标本共52例。利用SP免疫组化法检测眼睑部基底细胞癌组织中CD44V6和Bcl-2蛋白的表达。随访5年,观察复发情况。结果 CD44V6蛋白的阳性表达率在眼睑部基底细胞癌分化型(0)与未分化型(35.7%)比较以及复发者(57.1%)和未复发者(2.2%)比较,差异有统计学意义(P均<0.01)。Bcl-2蛋白的阳性表达率在分化型(94.7%)与未分化型(85.7%)比较差异无统计学意义(P>0.05);在复发者(57.1%)和未复发者(97.8%)比较差异有统计学意义(P<0.01)。结论眼睑部基底细胞癌未分化组CD44V6阳性率较高,未复发组Bcl-2阳性率较高;CD44V6和Bcl-2可能参与了眼睑部基底细胞癌的发生发展过程。
Objective To investigate the expression of CD44V6 and Bcl-2 in basal cell carcinoma of the eyelid and its significance. Methods Selected 52 cases of basal cell carcinoma of the eyelid surgically removed from 2000 to 2010 in ophthalmology. The expression of CD44V6 and Bcl-2 protein in basal cell carcinoma of the eyelid was detected by SP immunohistochemistry. Followed up for 5 years to observe the recurrence. Results The positive rate of CD44V6 protein in eyelid basal cell carcinoma was significantly higher than that in undifferentiated (35.7%) and recurrence (57.1%) and non-relapsed (2.2%) P <0.01). The positive expression rate of Bcl-2 protein was not significantly different between the differentiated type (94.7%) and undifferentiated type (85.7%) (P> 0.05) The difference was statistically significant (P <0.01). Conclusions The positive rate of CD44V6 in the undifferentiated group of eyelid basal cell carcinoma is high, while the positive rate of Bcl-2 in non-relapsed group is higher. CD44V6 and Bcl-2 may be involved in the occurrence and development of basal cell carcinoma of the eyelid.