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目的进一步探讨肿瘤坏死因子(tumor necrosis factor,TNF)-α基因启动子-238位点多态性与强直性脊柱炎(ankylosing spondylitis,AS)的相关情况。方法通过中国生物医学文献数据库、中国期刊全文数据库、万方、维普、PubMed、Cochrane Library、Ovid、Wiley Online Library、EBSCO、Elsevier Science Direct、Springer、Goolge scholar数据库检索国内外已发表或未发表TNF-α基因启动子-238位点多态性与AS相关的病例对照研究,采用Meta分析综合定量分析最终纳入的文献。结果 17篇文献共纳入1 899例患者和2 381例对照,Meta分析结果提示在总人群(OR=0.96,95%CI:0.76~1.21,P=0.720)、亚洲人群(OR=1.38,95%CI:0.84~2.24,P=0.200)、非亚洲人群(OR=0.97,95%CI:0.61~1.55,P=0.900)均不能明确TNF-α-238位点(GA+AA)vs.GG基因型与AS间存在关联;非亚洲人群(OR=0.40,95%CI:0.08~2.03,P=0.270)均不能明确TNF-α-238位点(GG+GA)vs.AA基因型与AS间存在关联;在总人群(OR=0.95,95%CI:0.52~1.74,P=0.870)、亚洲人群(OR=1.39,95%CI:0.90~2.14,P=0.140)、非亚洲人群(OR=0.79,95%CI:0.33~1.86,P=0.590)均不能明确TNF-α-238位点G vs.A等位基因多态性与AS间存在关联。结论 Meta分析显示总人群、亚洲人群和非亚洲人群TNF-α-238位点各基因型和等位基因多态性与AS间均未显示关联。
Objective To investigate the relationship between the promoter-238 locus polymorphism of TNF-α gene and ankylosing spondylitis (AS). Methods The domestic and foreign published or unpublished data of TNF-alpha and TNF-alpha were searched through the Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Wanfang, VIP, PubMed, Cochrane Library, Ovid, Wiley Online Library, EBSCO, Elsevier Science Direct, Springer, α gene promoter-238 site polymorphism and AS-related case-control study, the use of Meta analysis of quantitative analysis of the final inclusion of the literature. Results A total of 1899 patients and 2 381 controls were included in 17 articles. The results of Meta analysis showed that in the Asian population (OR = 0.38, 95% CI: 0.76 to 1.21, P = 0.720) CI: 0.84-2.24, P = 0.200), TNF-α-238 site (GA + AA) vs. GG gene was not found in non-Asian population (OR = 0.97,95% CI: 0.61-1.55, P = 0.900) There was a correlation between ASA genotypes and AS in non-Asian population (OR = 0.40, 95% CI: 0.08-2.03, P = 0.270) (OR = 1.39, 95% CI: 0.90 ~ 2.14, P = 0.140) in non-Asian population (OR = 0.95,95% CI: 0.52-1.74, P = 0.870) 0.79, 95% CI: 0.33-1.86, P = 0.590) failed to confirm the association of G vs. A allele at TNF-α-238 loci with AS. Conclusions Meta-analysis showed no association between genotype and allele polymorphisms of TNF-α-238 loci in the general population, Asian population and non-Asian population.