论文部分内容阅读
目的探讨血清半乳糖凝集素-3(Gal-3)在糖尿病慢性肾脏疾病(CKD)中的临床价值。方法将180例患者分为糖尿病无肾病(DM)组55例,糖尿病慢性肾脏疾病(D-CKD)组66例和非糖尿病慢性肾脏疾病(ND-CKD)组59例,另选60名健康成年人作为健康对照(NC)组,并于入院第1天进行肾功能、HbA1c、血清Gal-3及尿四项蛋白的检测,留取24h尿进行24hUAlb分析。结果 D-CKD组与DM组相比,糖尿病病程[(10.3±5.2)vs(4.7±2.7)年],HbA1c[(7.5±3.2)vs(6.8±2.8)%],24hUAlb[(4.39±1.45)vs(0.22±0.12)g/24h],Gal-3水平[(12.5±3.7)vs(6.7±3.0)ng/ml],以及肾功能、尿四项蛋白比较差异均有统计学意义(P<0.05);D-CKD组与ND-CKD组相比,糖尿病病程[(10.3±5.2)vs 0年],HbA1c[(7.5±3.2)vs(4.5±1.4)%],24UAlb[(4.39±1.45)vs(2.78±0.76)g/24h]及Gal-3水平[(12.5±3.7)vs(5.5±2.4)ng/ml]比较差异均有统计学意义(P<0.05)。D-CKD患者血清logGal-3与logGlu及年龄无相关性,与logUAlb和糖尿病病程呈正相关(r=0.621、0.761,P<0.01)。多因素Logistic回归分析结果显示,糖尿病病程、HbA1c、Gal-3与D-CKD独立相关。结论血清Gal-3能反映D-CKD肾小球受损程度,并与糖尿病病程相关,具有临床应用价值。
Objective To investigate the clinical value of serum galectin-3 (Gal-3) in diabetic chronic kidney disease (CKD). Methods 180 patients were divided into diabetic nephropathy (DM) group 55 cases, diabetic chronic kidney disease (D-CKD) group 66 cases and non-diabetic chronic kidney disease (ND-CKD) group 59 cases, another 60 healthy adults (NC) group. Renal function, HbA1c, Serum Gal-3, and urinary protein were detected on the first day of hospitalization. 24-h urine was collected for 24-UAlb analysis. Results Compared with DM group, the duration of diabetes [(10.3 ± 5.2) vs (4.7 ± 2.7) years], HbA1c [(7.5 ± 3.2) vs (6.8 ± 2.8)%], 24hUAlb [(4.39 ± 1.45 ) vs (0.22 ± 0.12) g / 24h] and Gal-3 levels (12.5 ± 3.7 vs 6.7 ± 3.0 ng / ml, respectively) (P <0.05). Compared with ND-CKD group, the duration of diabetes (10.3 ± 5.2 vs 0 years), HbA1c [(7.5 ± 3.2) vs (4.5 ± 1.4)%], 24UAlb [(4.39 ± 1.45) vs (2.78 ± 0.76) g / 24h and Gal-3 levels (12.5 ± 3.7 vs 5.5 ± 2.4) ng / ml, respectively (P 0. 05). There was no correlation between logGal-3 and logGlu and age in patients with D-CKD, which was positively correlated with the course of logUAlb and diabetes (r = 0.621,0.761, P <0.01). Multivariate logistic regression analysis showed that the duration of diabetes, HbA1c, Gal-3 and D-CKD were independently related. Conclusion Serum Gal-3 can reflect the degree of glomerular damage of D-CKD and is related to the course of diabetes mellitus, which has clinical value.