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为了探讨人巨细胞病毒（Ｈｕｍａｎｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ，ＨＣＭＶ）与宫颈癌发生之间的关系，我们利用紫外线灭活的ＨＣＭＶ诱发小鼠宫颈癌的动物模型进行了研究。经紫外线灭活的ＨＣＭＶ液接种于小鼠宫颈部，３次／周×８周，接着以巴豆油按同样的方法２次／周×４周进行处理。同时设立ＨＣＭＶ及人胚肺细胞ＨＥＬ培养液对照组等。经２０个月后，折颈处死动物，取出完整的生殖道作病理学检测，结果发现：ＨＣＭＶ组宫颈癌前病变率为２７．８％（２３／８３），癌发率为２０．５％（１７／８３）；ＨＥＬ培养液对照组仅１例发生宫颈不典型增生（ＣＩＮⅠ），癌发率为零（０／３１）。在ＨＣＭＶ加巴豆油组，宫颈不典型增生的发生率为２６．４％（１４／５３）。而癌发率则提高到５２．８％（２８／５３）。此结果提示，人巨细胞病毒ＡＤ１６９株具有在体内转化宫颈内皮细胞，从而诱发宫颈癌的能力，巴豆油能够促进ＨＣＭＶ的诱癌能力，因此也讨论了ＨＣＭＶ致癌机制。
To investigate the relationship between human cytomegalovirus (HCMV) and cervical cancer, we studied the animal model of cervical cancer induced by UV-inactivated HCMV. The UV-inactivated HCMV solution was inoculated into the mouse cervix 3 times/week x 8 weeks, followed by treatment with croton oil 2 times/week x 4 weeks in the same manner. At the same time, HCMV and human embryo lung cell HEL culture fluid control groups were established. After 20 months, the animals were killed by folding their necks and the complete genital tract was removed for pathological examination. The results showed that the precancerous lesion rate in the HCMV group was 27.8% (23/83), and the cancer incidence was 20.5%. (17/83); HEL culture fluid control group only 1 case of cervical dysplasia (CINI), cancer rate was zero (0/31). In the HCMV Gabba oil group, the incidence of cervical dysplasia was 26.4% (14/53). The incidence of cancer increased to 52.8% (28/53). This result suggests that the human cytomegalovirus AD169 strain has the ability to transform cervical endothelial cells in vivo, thereby inducing cervical cancer. Croton oil can promote the cancer-inducing ability of HCMV, and therefore the mechanism of HCMV carcinogenesis is also discussed.