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转基因动物技术在药理学和毒理学研究中的应用有十分广泛的前景，目前已建立了早老性痴呆、胰岛素依赖性糖尿病、乙型肝炎病毒感染和人类免疫缺陷病毒感染等多种复杂疾病的转基因动物模型，用于新药的筛选和评价。此外，还制备了５－羟色胺受体缺陷小鼠、高血压转基因大鼠、γ干扰素基因和多药耐药基因缺陷转基因小鼠，分别用于５－羟色胺受体、肾素、白介素１２和多药耐药蛋白的药理特性研究。在毒理学中的应用包括致突变试验、致癌试验、ＤＮＡ损伤与修复、化学致癌危险度评定和毒理学机制的研究等。
The application of transgenic animal technology in pharmacology and toxicology research has a very broad prospect. At present, transgenic genes of many complex diseases such as Alzheimer’s disease, insulin-dependent diabetes mellitus, Hepatitis B virus infection and human immunodeficiency virus infection have been established Animal models for the screening and evaluation of new drugs. In addition, serotonin receptor deficient mice, hypertensive transgenic rats, gamma interferon genes and multidrug resistance gene-deficient transgenic mice were also prepared for serotonin receptors, renin, interleukin 12 and Study on pharmacological properties of multidrug resistance protein. Applications in toxicology include mutagenicity testing, carcinogenicity testing, DNA damage and repair, chemical carcinogenicity risk assessment, and toxicological mechanisms.