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洛美沙星(Lomefloxacin,LFLX)为近年来新开发的第三代喹诺酮类抗菌药。具有抗菌谱广,高效低毒等特点~([1])。我们按中国药典2000年版“细菌内毒素检查法”中干扰试验的基本原理及细菌内毒素检查法应用指导原则~([2]),对盐酸洛美沙星葡萄糖注射液的细菌内毒素检测方法进行了研究。1实验材料1.1鲎试剂(批号:000312-2,灵敏度为0.25Eu/ml,福州新北生化工业有限公司。批号:961115,灵敏度为0.125Eu/ml,厦门鲎试剂厂)1.2细菌内毒素工作标准品(批号:9808,40Eu/支,中
Lomefloxacin (LFLX) is a newly developed third-generation quinolone antibacterial agent in recent years. With broad antibacterial spectrum, high efficiency and low toxicity and so on ~ ([1]). We according to the Chinese Pharmacopoeia 2000 edition “bacterial endotoxin test method ” in the basic principle of interference test and bacterial endotoxin test method for the application of guidelines [2]), Lomefloxacin hydrochloride glucose injection bacterial endotoxin test Methods were studied. 1 Experimental material 1.1 鲎 reagent (batch number: 000312-2, the sensitivity of 0.25Eu / ml, Fuzhou New North Biochemical Industry Co., Ltd. batch number: 961115, the sensitivity of 0.125Eu / ml, Xiamen 鲎 reagent plant) 1.2 bacterial endotoxin work standards (Lot number: 9808,40Eu / support, in